Rhodium(I)‐Catalyzed Arylation of β‐Chloro Ketones and Related Derivatives through Domino Dehydrochlorination/ Conjugate Addition

Abstract

Abstract Highly efficient arylations of β‐chloro ketones and their ester and amide derivatives were achieved by means of domino dehydrochlorination/Rh(I)‐catalyzed conjugate addition. In situ generated vinyl ketones and their analogues were identified as the reaction intermediates. The present synthetic protocol provides a concise route to (chiral) β‐aryl ketones, esters, and amides.