Eye lesions in Sprague-Dawley rats: type and incidence in relation to age

Abstract

Ophthalmological examination of about 3000 rats up to 2 years old, untreated controls in toxicological studies, has provided information on the varying incidence with age of various spontaneous ophthalmic lesions of low frequency. Such information is of fundamental value in assessing the effect of administered compounds on ophthalmic changes.