An Investigation of the Traditional Algorithm-Based Designs for Phase 1 Cancer Clinical Trials

Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer

John O’Quigley, Margaret S. Pepe, Lloyd D. Fisher · Biometrics · 1990 · 1.6K citations

Medicine, Biostatistics, Oncology +14

Some practical improvements in the continual reassessment method for phase I studies

Steven N. Goodman, Marianna Zahurak, Steven Piantadosi · Statistics in Medicine · 1995 · 474 citations

Pharmacy, Pharmacology, Dose-response Modeling +11

A comparison of two phase I trial designs

Edward L. Korn, Douglas Midthune, T. Timothy Chen et al. · Statistics in Medicine · 1994 · 300 citations

Public Health, Biostatistics, Oncology +12

Practical modifications of the continual reassessment method for phase i cancer clinical trials

Douglas E. Faries · Journal of Biopharmaceutical Statistics · 1994 · 237 citations

Pharmacy, Oncology, Pharmacology +16

Statistical properties of the traditional algorithm-based designs for phase I cancer clinical trials

Yong Lin · Biostatistics · 2001 · 170 citations

Medicine, Biostatistics, Oncology +9