PubMed · 2006 · 109 citations · 11 references
MedicineOncologyPharmacologyCancer PharmacologyChemotherapyOncology PharmacotherapyHepatobiliary ImagingLiver MetastasisMetastatic Cancer ManagementMetastatic Disease ManagementMetastatic Disease TreatmentTherapy Response AssessmentContrast EnhancementIrinotecan-based TherapyLiver Metastases ManagementLiver Metastases TreatmentLiver Tumor TherapyLocal Contrast EnhancementMetastatic Liver Disease TreatmentTumor Embolization
PURPOSE: The purpose of the study was to evalutate the feasibility of irinotecan drug-eluting beads (DC Bead) administered as trans-arterial chemoembolization (TACE) in patients with liver metastases from colorectal cancer (CRC). PATIENTS AND METHODS: Ten patients with liver metastases from CRC were treated with TACE adopting irinotecan-eluting beads at a dose of 100 mg every 3 weeks. Computed Tomography (CT) was performed 24h before and after TACE. RESULTS: TACE with irinotecan eluting beads was found to be feasible and well-tolerated. Right upper quadrant pain (RUQP) lasting 4 days (range 2-7) was reported by all the patients. After 30 days, a reduction >50% of CEA levels and of the lesional contrast enhancement was observed in all the patients. CONCLUSION: Irinotecan drug-eluting beads administered as TACE were shown to be active and safe in patients with liver metastases from CRC.
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Factors influencing the natural history of colorectal liver metastases
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