Association of Systemic Lupus Erythematosus With Decreased Immunosuppressive Potential of the IgG Glycome

Abstract

The IgG glycome in SLE patients is significantly altered in a way that decreases immunosuppressive action of circulating immunoglobulins. The magnitude of observed changes is associated with the intensity of the disease, indicating that aberrant IgG glycome composition or changes in IgG glycosylation may be an important molecular mechanism in SLE.