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Publication | Open Access

Surfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRPα

DOIFull Paper Access

198

Citations

55

References

2008

Year

William J. Janssen, Kathleen A. McPhillips, Matthew Dickinson, Derek J. Linderman, Konosuke Morimoto, Yi Xiao, Kelly M. Oldham, R. William Vandivier, Peter M. Henson, Shyra J. Gardai
American Journal of Respiratory and Critical Care Medicine

Abstract

SP-A and SP-D tonically inhibit alveolar macrophage phagocytosis by binding SIRP alpha. During acute pulmonary inflammation, defects in apoptotic cell clearance are overcome by recruited mononuclear phagocytes.

References

YearCitations

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