Concepedia

Simulation of the oxidative metabolism of diclofenac by electrochemistry/(liquid chromatography/)mass spectrometry

Helene Faber, Daniel Melles, Christine Brauckmann, Christoph A. Wehe, Kristina S. Wentker, Uwe Kärst

Analytical and Bioanalytical Chemistry · 2012 · 64 citations · 17 references

DOI

Concepts

References

17

Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways

Roque Bort, Katherine Macé, Alan R. Boobis et al. · Biochemical Pharmacology · 1999 · 236 citations

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Negative Ion Tandem Mass Spectrometry for the Detection of Glutathione Conjugates

Christine M. Dieckhaus, Carmen Fernández‐Metzler, Richard C. King et al. · Chemical Research in Toxicology · 2005 · 220 citations

, , +17

Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions

Ulrik Jurva, Håkan Wikström, Lars Weidolf et al. · Rapid Communications in Mass Spectrometry · 2003 · 208 citations

, , +11

Metabolic Activation of Diclofenac by Human Cytochrome P450 3A4:  Role of 5-Hydroxydiclofenac

Sijiu Shen, Michael R. Marchick, Margaret R. Davis et al. · Chemical Research in Toxicology · 1999 · 183 citations

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Diclofenac Covalent Protein Binding Is Dependent on Acyl Glucuronide Formation and Is Inversely Related to P450-Mediated Acute Cell Injury in Cultured Rat Hepatocytes

Urs A. Boelsterli · Toxicology and Applied Pharmacology · 1993 · 172 citations

, , +14