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Studies on organic fluorine compounds. Part 37. Studies on steroids. Part 78. Synthesis of 24,24-difluoro- and 24ξ-fluoro-25-hydroxyvitamin D<sub>3</sub>
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1982
Year
Vitamin NutritionMedicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryDerivative (Chemistry)BiochemistryVitamin D3 MetabolismNatural Sciences24ξ-Fluoro-25-hydroxyvitamin D3MedicineFluorous SynthesisOrganic ChemistryOrganic Fluorine CompoundsChemistryMetabolismPharmacologyFluorine SubstituentsOxidative Stress
To clarify the physiological significance of C-24 hydroxylation in vitamin D3 metabolism, vitamin D3 compounds blocked at C-24 by fluorine substituents, namely 24,24-difluoro-25-hydroxyvitamin D3(1) and 24ξ-fluoro-25-hydroxyvitamin D3(2) have been synthesized from 3β-hydroxychol-5-en-24-oic acid (13).