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O-aryl S-methyl phosphorochloridothioates: terminal phosphorylating agents in the phosphotriester approach to oligonucleotide synthesis
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1978
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EngineeringMolecular BiologyOrganic ChemistryO-aryl S-methyl PhosphorothioatesChemistryChemical DerivativeBiosynthesisStereoselective SynthesisO-aryl S-methyl PhosphorochloridothioatesBiochemistryCorresponding Phosphate EstersOligonucleotideTerminal Phosphorylating AgentsPhosphotriester ApproachBio-orthogonal ChemistryBiomolecular EngineeringProtein PhosphorylationNatural SciencesDerivative (Chemistry)Synthetic Chemistry
O-Aryl S-methyl phosphorothioates (e.g., 6), prepared by the action of O-aryl S-methyl phosphorochloridothioates (e.g., 4c) on alcohols may be converted into the corresponding phosphate esters (e.g., 7b) by treatment first with 4-nitrobenzaldoximate ion and then with iodine in aqueous pyridine.