Biodegradable ZnO@polymer Core–Shell Nanocarriers: pH‐Triggered Release of Doxorubicin In Vitro

Abstract

Luminescent ZnO@polymer core–shell nanoparticles were synthesized and loaded with doxorubicin (DOX) for the treatment of human brain cancer cells. Analyses by confocal laser scanning microscopy proved that the ZnO@polymer–DOX nanocomposites were decomposed at lysosomes to release DOX molecules, which penetrated into the nucleus and finally killed the cells (see picture).