Insulin Induces Upregulation of Vascular AT₁Receptor Gene Expression by Posttranscriptional Mechanisms

Abstract

Insulin-induced upregulation of the AT1 receptor by posttranscriptional mechanisms may explain the association of hyperinsulinemia with hypertension and arteriosclerosis, because activation of the AT1 receptor plays a key role in the regulation of blood pressure and fluid homeostasis.