DergiPark (Istanbul University) · 2004 · 49 citations · 49 references
Open access
Veterinary MedicineDermatologySurgeryCell TherapyRegenerative MedicineWound HealingMoist Wound HealingSkin RegenerationWound AssessmentWound Bed PreparationWound CareWound ManagementAutologous Skin SubstitutesCutaneous Wound HealingGrowth FactorsGrowth Factors In RepairInflammation In Wound HealingSkin SubstitutesStem Cell-based TherapyWound Healing Pathophysiology
Wound biology is increasingly viewed at the cellular and molecular level, with growth factors, cytokines, proteases, and adhesion molecules recognized as key players, and clinical practice now emphasizes moist healing, wound bed preparation, and assessment while therapeutic options rapidly expand. The article reviews a spectrum of current and emerging wound therapies, including physical modalities such as negative‑pressure, warming, and electrical stimulation; biological approaches like larva therapy, skin substitutes, stem cells, growth factors, and gene therapy; and miscellaneous options such as hyperbaric oxygen and advanced dressings.
Wound biology is complex. Wounds which were until recently seen only as defects in tissues are now increasingly interpreted in cellular and molecular terms. Growth factors, cytokines, proteases and adhesion molecules which participate in wound healing are discussed in this article. From a clinical perspective, conceptual shifts of importance, including moist wound healing, wound bed preparation and wound assessment, are presented. The frontiers of therapeutics employed in wound healing continue to advance with an increasing array of modalities joining the ranks at a regular pace. A range of currently available as well as evolving therapies- physical (topical negative pressure therapy, warming, electrical stimulation), biological (larva therapy, skin substitutes, stem cell therapy, growth factors, gene therapy) and of a miscellaneous variety (hyperbaric oxygen, dressings)- are appraised.
49
Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.
Daniel E. Gómez, Daniel F. Alonso, Hitoshi Yoshiji et al. · PubMed · 1997 · 1.5K citations