Enhancement of virus-induced leukemias and sarcomas in F 1 hybrid mice inoculated with parental spleen cells.

Abstract

Summary The inoculation of parental spleen cells in F 1 hybrid mice favors the growth of both Graffi leukemia virus-induced lymphomas and murine sarcoma virus-induced rhabdomyosarcomas. Histocompatibility typing showed that the lymphomas originated from the hybrids and not from the parents. These observations from experiments with a known leukemogenic virus support the theory of the role of an “endogenous” leukemia virus in previously reported lymphomas arising during chronic allogeneic disease, but they suggest that the parental spleen cells play an active role in enhancing the phenomenon. The mechanisms of this action are briefly discussed.