Paclitaxel as second and subsequent therapy for metastatic breast cancer: activity independent of prior anthracycline response.

Abstract

Paclitaxel's clinically significant activity against metastatic breast cancer extends to patients with many prior chemotherapy regimens. The lack of impact of prior doxorubicin therapy on the likelihood of subsequent response to paclitaxel suggests an important role for this agent in the treatment of refractory metastatic breast cancer.