Phytotherapy Research · 2001 · 90 citations · 6 references
MedicineBotanyPharmacologyDiabetologyPlant BiochemistrySeed ScienceDiabetes ControlDiabetes ManagementDiabetes MellitusDiabetes PharmacotherapyGlycemic ControlOral Antidiabetic AgentsAntidiabetic ActivityAntidiabetic Drug TherapyBlood Glucose RegulationDiabetic ComplicationsExtractOral Antidiabetic TherapyOral Glucose AdministrationOral Hypoglycemic Therapy
The hypoglycaemic activity of Punica granatum Linn. (Family Punicaceae) seed extract on rats made diabetic by streptozotocin (STZ) was investigated. The methanol extract of the seed at doses of 300 and 600 mg/kg, and chlorpropamide 200 mg/kg was administered to STZ diabetic rats. The seed extract (150, 300 and 600 mg/kg, orally) caused a significant reduction of blood glucose levels in STZ induced diabetic rats by 47% and 52%, respectively, at the end of 12 h.
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Studies on the diabetogenic action of streptozotocin
Nathan Rakieten · Medical Entomology and Zoology · 1963 · 821 citations
Studies of the Diabetogenic Action of Streptozotocin.
Ana Paula Franco Lambert, Lelio Orci, Raymond Pictet et al. · Experimental Biology and Medicine · 1967 · 489 citations