Alkyne Phosphonites for Sequential Azide–Azide Couplings

Abstract

When Staudinger meets Huisgen! A combination of the copper-catalyzed variant of the Huisgen azide–alkyne cycloaddition (CuAAC) and the Staudinger reaction, the two most successful chemoselective reactions for the transformation of azides, leads to a chemical method that allows the sequential coupling of two different azido building blocks in high yields. This modular procedure enables a final metal-free conjugation of functional building blocks to azides. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.