Concepedia

Publication | Closed Access

Increased expression of cytoplasmic HuR in familial adenomatous polyposis

DOI

27

Citations

0

References

2008

Year

Lodewijk A.A. Brosens, Josbert J. Keller, Leena Pohjola, Caj Haglund, Folkert H.M. Morsink, Christine A. Iacobuzio–Donahue, Michael Goggins, Francis M. Giardiello, Ari Ristimäki, G. Johan A. Offerhaus
Cancer Biology & Therapy

Abstract

HuR is increasingly expressed in the cytoplasmic epithelial compartment in consecutive stages of the adenoma-carcinoma sequence in FAP. Also, COX-2 levels correlate with cytoplasmic expression of HuR in colonic epithelium of FAP patients and in sporadic colorectal cancer specimens. The role of cytoplasmic expression of HuR as a biomarker for progression of adenomas in FAP needs further study.