Chromium(0)‐Catalyzed Tandem Cyclization of α,β‐Unsaturated Thioimidates Containing an Enyne Moiety

Abstract

Bicyclic: The diastereoselective synthesis of functionalized 1-azabicyclo[5.3.0]decane derivatives proceeds through 1,7-electrocyclization of the zwitterionic intermediates that are formed in the cyclization of α,β-unsaturated thioimidates containing an enyne moiety (see scheme). Furthermore 1,4-addition of nucleophiles to α,β-unsaturated carbene complex intermediates was also achieved.