<i>ERG</i> and <i>CHD1</i> heterogeneity in prostate cancer: Use of confocal microscopy in assessment of microscopic foci

Abstract

These results demonstrate the ability of confocal microscopy and FISH to identify the cell-to-cell differences in common gene fusions such as TMPRSS2-ERG that may arise independently within the same tumor focus. These data support the need to study complimentary approaches to assess genetic changes that may stratify therapy based on predicted sensitivities.