Bilateral urinary kallikrein excretion in the Goldblatt hypertensive rat

Abstract

Separate kallikrein excretions [RIA of generated Bradykinins (BK)] and renal functions were measured in 32 two-kidney, one-clip Goldblatt hypertensive (GH) and in 16 sham-operated (SO) rats either one, two, three or four weeks after operation. Mean blood pressure and plasma renin activity were higher in GH rats than in the respective controls. In GH rats, kallikrein excretion was lower from the clipped kidney than from the controlateral one (114 +/- 63 vs 220 +/- 87 ng BK min-1 per 30 min urine collection at week 1, P less than 0.05; 151 +/- 94 vs 425 +/- 125 ng BK min-1 per 30 min urine volume at week 4, P less than 0.01). While the excretion was normal from the controlateral kidney, GH rats had lower total kallikrein excretions than SO rats (335 +/- 138 vs 476 +/- 81 ng BK min-1 per 30 min urine volume at week 1, P less than 0.05; 556 +/- 179 vs 1078 +/- 191 ng BK min-1 per 30 min urine volume at week 4, P less than 0.01). Urinary kallikrein excretion is decreased in 2K-1C Goldblatt hypertension from one week to four weeks after clipping on account of an exclusive reduction in that from the stenotic kidney.