Active Implant Combining Human Stem Cell Microtissues and Growth Factors for Bone-Regenerative Nanomedicine

Abstract

Furthermore, in this study, we have shown that by combining BMP-7 with these MSC MTs in this double 3D environment, we further accelerate bone growth in vivo. The strategy described here should enhance the efficiency of therapeutic implants compared with current simplistic approaches used in the clinic today based on collagen implants soaked in bone morphogenic proteins.