Science · 1997 · 1.6K citations · 12 references
MedicineNeurosciencePsychiatryAddiction PsychiatryPsychopharmacologySubstance Use DisordersAddictionAddiction NeurobiologyDrug DependenceDrugs Of AbusePsychosocial InterventionsSubstance UseChronic Drug UseCompulsive ConsumptionCompulsive DisordersCompulsive Drug UseCompulsive UseDisorderNeurobiology Of DependenceSocial Context
Scientific advances over the past 20 years have shown that drug addiction is a chronic, relapsing disease that results from the prolonged effects of drugs on the brain. As with many other brain diseases, addiction has embedded behavioral and social-context aspects that are important parts of the disorder itself. Therefore, the most effective treatment approaches will include biological, behavioral, and social-context components. Recognizing addiction as a chronic, relapsing brain disorder characterized by compulsive drug seeking and use can impact society's overall health and social policy strategies and help diminish the health and social costs associated with drug abuse and addiction.
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Rose Z. Terwilliger, Dana Beitner‐Johnson, Kevin A. Sevarino et al. · Brain Research · 1991 · 540 citations · Full text
Myths about the treatment of addiction
C. O'Brien, A. Thomas McLellan · The Lancet · 1996 · 517 citations · Full text
Medicine, Psychiatry, Psychology +10
Effects of chronic cocaine abuse on postsynaptic dopamine receptors
Nora D. Volkow, Joanna S. Fowler, Alfred P. Wolf et al. · American Journal of Psychiatry · 1990 · 416 citations
Medicine, Neuroscience, Pharmacology +17