Different Roles of Pummelo Furanocoumarin and Cytochrome P450 3A5*3 Polymorphism in the Fate and Action of Felodipine - Concepedia

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Different Roles of Pummelo Furanocoumarin and Cytochrome P450 3A5*3 Polymorphism in the Fate and Action of Felodipine

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References

2007

Year

Lian‐Qing Guo, Qiaoyun Chen, Xuan Wang, Yuxiu Liu, Xiao-Man Chu, Xiaomei Cao, Jin‐Heng Li, Yasushi Yamazoe

Current Drug Metabolism

Abstract

This work supports the hypothesis that CYP3A inhibition by furanocoumarins caused pummelo fruit juice-drug interaction; while the role of CYP3A5 in the population pharmacokinetics of felodipine and blood pressure response appear to be limited.