Concepedia

Efficient automated assessment of genetic abnormalities detected by fluorescence in situ hybridization on brush cytology in a Barrett esophagus surveillance population

Agnieszka Magdalena Rygiel, Jantine W.P.M. van Baal, Francesca Milano, Kenneth K. Wang, Febo J. ten Kate, Paul Fockens, Wilda Rosmolen, Jacques Bergman, Maikel P. Peppelenbosch, Kausilia K. Krishnadath

Cancer · 2007 · 43 citations · 30 references

DOIFull text

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Abstract

The current investigation indicated that the CytoVison SPOT AX is an objective, efficient system for the analysis of DNA-FISH on BE brush cytology and is applicable for analyzing large populations of BE patients. In the current study cohort, the loss of 17p13.1 (p53), Y chromosome loss, and polysomy of chromosomes 17 and 9 were correlated with increasing grade of dysplasia in patients with BE.

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