Glucose Metabolic Rate Kinetic Model Parameter Determination in Humans: The Lumped Constants and Rate Constants for [¹⁸F]Fluorodeoxyglucose and [¹¹C]Deoxyglucose

TLDR

The study aimed to determine the rate constants and lumped constants for [18F]FDG and [11C]DG in humans for use in the glucose metabolic rate kinetic model. The constants were derived from PET measurements of tracer kinetics in human subjects. The measured lumped constants were 0.52 ± 0.028 for [18F]FDG and 0.56 ± 0.043 for [11C]DG; the rate constants for gray matter were 0.095, 0.125, 0.069, 0.0055 and for white matter 0.065, 0.126, 0.066, 0.0054; whole‑brain glucose metabolic rates were 5.66 ± 0.37 and 4.99 ± 0.23 mg/100 g/min for [18F]FDG and [11C]DG, respectively, with no significant difference and agreement with literature.

Abstract

The rate constants and lumped constants (LCs) for [ 18 F]fluorodeoxyglucose ([ 18 F]FDG) and [ 11 C]deoxyglucose ([ 11 C]DG) were determined in humans for the glucose metabolic rate kinetic model used to measure local cerebral glucose consumption. The mean values (±SE) of the LCs for [ 18 F]FDG and [ 11 C]DG are 0.52 ± 0.028 (n = 9) and 0.56 ± 0.043 (n = 6), respectively. The mean values (±SE) of the rate constants k* 1 , k* 2 , k* 3 , and k* 4 for [ 18 F]FDG for gray matter are 0.095 ± 0.005, 0.125 ± 0.002, 0.069 ± 0.002, and 0.0055 ± 0.0003, respectively. The corresponding values for white matter are 0.065 ± 0.005, 0.126 ± 0.003, 0.066 ± 0.002, and 0.0054 ± 0.0006, respectively. Using these values and previously published values for the rate constants for [ 11 C]DG, the average whole-brain metabolic rates for glucose in normal subjects measured with [ 18 F]FDG and [ 11 C]DG are 5.66 ± 0.37 (n = 6) and 4.99 ± 0.23 (n = 6) mg/100 g/min, respectively. These values are not significantly different ( t = 1.56, p > 0.10) and agree well with reported values in the literature determined by means of the Kety-Schmidt technique.