Molecular Genetic and Functional Characterization Implicate Muscle-Restricted Coiled-Coil Gene ( <i>MURC</i> ) as a Causal Gene for Familial Dilated Cardiomyopathy

Abstract

MURC mutations impart loss-of-function effects on MURC functions and probably are causal variants in human DCM. The causal role of a deletion mutation in HCM is uncertain.