Synthesis of Tetrahydropyridazines by a Metal–Carbene‐Directed Enantioselective Vinylogous NH Insertion/Lewis Acid‐Catalyzed Diastereoselective Mannich Addition

Abstract

A versatile cascade of reactions, triggered by Rh(II)-catalyzed diazo decomposition followed by a vinylogous N-H insertion/Lewis acid catalyzed Mannich addition, that produces highly substituted 1,2,3,6-tetrahydropyridazines in up to 97 % ee with high yield and diastereocontrol has been developed.