Gastroprotective Activity of Melatonin and Its Precursor, L-Tryptophan, against Stress-induced and Ischaemia-induced Lesions Is Mediated by Scavenge of Oxygen Radicals

Abstract

Melatonin and L-tryptophan protect the gastric mucosa from damage by stress and ischaemia reperfusion, and this action is mediated, at least in part, by the limitation in the free radicals, the stimulation of mucosal generation of PG and by the increase in gastric blood flow.