Phenotypic Characterization of Disseminated Cells with <i>TSC2</i> Loss of Heterozygosity in Patients with Lymphangioleiomyomatosis

Abstract

Our data support a common genetic origin of LAM cells in most patients with S-LAM, consistent with a metastatic model. In some cases, however, there was evidence for genetic heterogeneity between LAM cells in different sites or within a site.