Orthopaedic applications of bone graft & graft substitutes: a review.

TLDR

Bone grafting is essential for treating delayed union, malunion, and nonunion, but autologous bone is limited by availability and harvest complications, so substitutes that provide osteoconductive scaffolds, osteoinductive proteins, and osteogenic cells are increasingly important. This review aims to evaluate the current bone graft and graft substitute options for novel therapeutic approaches in orthopedic surgery. The authors performed a comprehensive literature review of available bone graft materials and substitutes, summarizing their composition, clinical applications, and therapeutic potential.

Abstract

Treatment of delayed union, malunion, and nonunion is a challenge to the orthopaedic surgeons in veterinary and human fields. Apart from restoration of alignment and stable fixation, in many cases adjunctive measures such as bone-grafting or use of bone-graft substitutes are of paramount importance. Bone-graft materials usually have one or more components: an osteoconductive matrix, which acts as scaffold to new bone growth; osteoinductive proteins, which support mitogenesis of undifferentiated cells; and osteogenic cells, which are capable of forming bone in the appropriate environment. Autologous bone remains the "gold standard" for stimulating bone repair and regeneration, but its availability may be limited and the procedure to harvest the material is associated with complications. Bone-graft substitutes can either substitute autologous bone graft or expand an existing amount of autologous bone graft. We review the currently available bone graft and graft substitutes for the novel therapeutic approaches in clinical setting of orthopaedic surgery.