The use of the RambergBäcklund rearrangement for the formation of aza-macrocycles: a total synthesis of manzamine C

Abstract

A total synthesis of the marine alkaloid manzamine C has been accomplished. A Ramberg-Bäcklund reaction was used as a key step to construct the required azacycloundecene ring.Key words: alkaloid, macrocycle, Ramberg–Bäcklund, manzamine C.