Anti-Ulcer Activity of the Ethanolic Extract of Combretum Dolichopetalum Root

Abstract

The Ethanolic Root Extract Of Combretum Dolichopetalum Induced Dose-Dependent Relaxation Effect On The Isolated Guinea Pig Ileum With An Ec5o Of 2.65 Mg/Ml, and Also Inhibited Contractile Responses Of The Ileum To Histamine (10/μg/Ml) and Acetylcholine (10/μg/Ml). The Extract Possessed Significant Dose-Dependent Anti-Ulcer Activity In Experimentally-Induced Acute Gastric Ulcers With Indomethacin and Cold Stress. The Anti-Ulcer Effect Of The Extract Could Be Due To Its Content Of Tannin and Saponin Or To Its Anticholinergic and Antihistaminic Activities, Or A Combination Of These Factors.