Larger dispersion of INa in female dog ventricle as a mechanism for gender-specific incidence of cardiac arrhythmias

Abstract

The larger dispersion of I(Na) amplitude within the female cardiac ventricle may contribute to the higher risk of arrhythmias in females. Testosterone modulates this dispersion. By decreasing the transmural dispersion of I(Na), testosterone may exert a protective effect against LQTS-related arrhythmias in males.