Catalytic Asymmetric Mannich Reaction of Glycine Derivatives with <i>N</i>‐Tosylimines using Copper(I)/TF‐BiphamPhos Complex

Abstract

Abstract The direct asymmetric Mannich reaction of glycine Schiff bases with N ‐tosylimines has been developed with the tetrakis(acetonitrile)copper(I) tetrafluoroborate [Cu(CH 3 CN) 4 BF 4 ]/TF‐BiphamPhos complex. This catalytic system performs well over a broad range of substrates, furnishing anti ‐adducts of various α,β‐diamino acid esters in good yields with up to 94:6 diastereoselectivity and 97% enantioselectivity.