Clinical Infectious Diseases · 2002 · 120 citations · 9 references
MedicineInfectious DiseasesNeurologyNeurocritical CareNeuroinfectious DiseasesNeurologic PharmacotherapyCentral Nervous System InfectionsHeadache DisordersHeadache ManagementIntracranial HypertensionIntracranial PressureIntracranial Pressure ManagementAdult MeningitisBicarbonate HomeostasisCerebrospinal Fluid Pressure MeasurementCryptococcal MeningitisIncreased Intracranial PressureIntracranial Hypertension In MeningitisNeurological Adverse EventsSerious Adverse Events
We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of >/=200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.
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