Comparison of SPIO and USPIO for in Vitro Labeling of Human Monocytes: MR Detection and Cell Function

Abstract

In vitro labeling of human monocytes is effective by using SPIOs, not USPIOs. Incubation with SPIOs (1.0 mg Fe/mL) results in efficient labeling detectable on MR images and does not affect cellular viability and activation markers such as cell migration and cytokine production.