Uncoupling Protein 2 Promoter Polymorphism −866G/A Affects Peripheral Nerve Dysfunction in Japanese Type 2 Diabetic Patients

Abstract

UCP2 promoter gene polymorphism -866 G/A was significantly associated with nerve conduction slowing and vasomotor sympathetic functions. These findings suggest that the higher UCP2 activity related to the A allele has an energy-depleting effect on peripheral nerve function in type 2 diabetic patients.