Control of transient lower oesophageal sphincter relaxations and reflux by the GABA _B agonist baclofen in patients with gastro-oesophageal reflux disease

Abstract

In patients with reflux disease, the GABA(B) agonist baclofen significantly inhibits gastro-oesophageal reflux episodes by inhibition of TLOSRs. These findings suggest that GABA(B) agonists may be useful as therapeutic agents for the management of reflux disease.