Click Chemistry: Copper Clusters Catalyse the Cycloaddition of Azides with Terminal Alkynes

Abstract

Abstract Air‐stable copper nanoclusters are good catalysts in the Cu(I)‐catalysed “click” cycloaddition of azides with terminal alkynes to give 1,4‐disubstituted 1,2,3‐triazoles. No additional base or reducing agent is required. The reaction kinetics using various copper catalyst types and the function of copper particles in this system are studied and discussed.