Antinuclear Antibody Reduces the Pregnancy Rate in the First IVF‐ET Treatment Cycle but Not the Cumulative Pregnancy Rate without Specific Medication

Abstract

These findings suggest that ANA might have an impact on implantation failure in women treated by IVF-ET or ICSI-ET. ANA reduced the pregnancy rates in the first IVF-ET or ICSI-ET cycles but not the cumulative pregnancy rates without medication. This indicates that the mechanisms of implantation failure by ANA could be solved, and effective and safe medication should be developed for better implantation rates, especially in the first treatment cycle.