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Vanadium(<scp>II</scp>)‐ and Niobium(<scp>III</scp>)‐Induced, Diastereoselective Pinacol Coupling of Peptide Aldehydes to <i>C</i><sub>2</sub>‐Symmetrical HIV‐Protease Inhibitors
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References
1994
Year
Combinatorial ChemistryMolecular BiologyOrganic ChemistryPeptide ScienceChemical BiologyPharmaceutical ChemistryMedicinal ChemistryNiobium CatalystsStereoselective SynthesisInhibitory ActivityDiastereoselective Pinacol CouplingBiochemistryPeptide AldehydesHomochiral Peptide AldehydesPharmacologyNatural SciencesPeptide SynthesisVanadium CatalystsMedicineSynthetic ChemistryDrug Discovery
Potent inhibitors of HIV-protease such as 1 can be produced on a kilogram scale by diastereoselective, reductive dimerization of homochiral peptide aldehydes. This is made possible by the use of niobium catalysts or vanadium catalysts generated in situ in the crucial reaction step. aryl = 1-naphthyl.
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