American Journal of Tropical Medicine and Hygiene · 2007 · 25 citations · 13 references
PharmacyInfectious DiseasesPharmacologyAntimicrobial PharmacotherapyClinical PharmacologyInfectious Disease PharmacotherapyAntiparasitic PharmacologyAntiparasitic PharmacotherapyAntiparasitic TherapyEssential MedicinesMalariaTreatmentAntimalarial AgentsAntimalarial ChemotherapyAntimalarial Drug CombinationsArtemisinin ResistanceChemotherapy Of MalariaPlasmodium FalciparumTherapeutic Efficacy AssessmentTreatment Of Malaria
Bangladesh faces increasing levels of chloroquine resistance, and drug sensitivity to sulfadoxine-pyremethamine is already compromised. Therefore, the Ministry of Health recently changed the national treatment guidelines to artemisinin-based combination therapies. The purpose of this study was to determine the baseline therapeutic efficacy of artemether-lumefantrine used as a six-dose regimen for the treatment of uncomplicated Plasmodium falciparum malaria. Sixty-seven patients were enrolled in the study; the cure rate in a 42-day follow-up after an adjustment by polymerase chain reaction was 94.3%. The treatment led to rapid fever (mean +/- SD = 25.82 +/- 12.14 hours) and parasite (30.36 +/- 19.43 hours) clearance. These data suggest that artemether-lumefantrine is a highly efficacious and well-tolerated treatment for uncomplicated P. falciparum malaria in Bangladesh.
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Weltgesundheitsorganisation · 2005 · 3.8K citations
Michèle van Vugt, A Brockman, B Gemperli et al. · Antimicrobial Agents and Chemotherapy · 1998 · 170 citations · Full text
Veterinary Medicine, Infectious Diseases, Pharmacotherapy +12