Synthese von 2,3‐Bis(ethoxycarbonyl)‐1<i>H</i>‐pyrrol‐1‐propionsäure‐ethylester

Abstract

Synthesis of Ethyl 2,3‐Bis(ethoxycarbonyl)‐1 H ‐pyrrole‐1‐propionate Ethyl 2,3‐bis(ethoxycarbonyl)‐1 H ‐pyrrole‐1‐propionate ( 7 ) can easily be obtained in high yields from ethyl 4‐iodobutyrate ( 1 ) via reaction with dibenzylamine and diethyl oxalate, catalytic debenzylation to diethyl cis ‐2,3‐pyrrolidinedicarboxylate ( 5 ), subsequent dehydrogenation to diethyl 1 H ‐pyrrole‐2,3‐dicarboxylate ( 6 ), and further N ‐alkylation to the desired title compound 7 .