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THE EFFECT OF CORTIN UPON THE RENAL EXCRETION OF SODIUM, POTASSIUM, CHLORIDE, INORGANIC PHOSPHOROUS AND TOTAL NITROGEN IN NORMAL SUBJECTS AND IN PATIENTS WITH ADDISON'S DISEASE1
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1937
Year
Total NitrogenHypertonicityUrologyAdrenal GlandRenal FunctionElectrolyte DisorderSodium HomeostasisMedicinePhysiologyLarge InjectionsElectrolyte DisturbanceElectrophysiologyRenal ExcretionEndocrinologyChronic Kidney DiseasePotassium HomeostasisNephrologyEffect Of Cortin
In another investigation (1) we have shown that amounts of cortin sufficient to maintain patients with severe Addison's disease have little or no effect on the electrolyte and nitrogen balance of normal human beings. There was still the possibility that very large doses of cortin might effect the balance in normal individuals. Cost makes the use of massive doses almost impossible in balance studies. However, when large doses are used the effect on the excretion of sodium, potassium and chloride is so prompt that balance studies are not required. The immediate effect of large injections of cortin on the renal excretion of sodium, potassium, chloride and total nitrogen is reported in this paper.