Regioselectivity with Hemispherical Chelators: Increasing the Catalytic Efficiency of Complexes of Diphosphanes with Large Bite Angles

Abstract

Control through molecular pockets: Calixarene-derived diphosphites provide effective hemispherical crowding about catalytic centers. When used in the palladium-catalyzed alkylation of cinnamyl acetate, regioselectivities higher than 98 % in favor of the linear product are observed. In the rhodium-catalyzed hydroformylation of styrene, these diphosphites lead to phenylpropionaldehyde with selectivities as high as 76 %. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z601978_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.