Nonmucoid<i>Pseudomonas aeruginosa</i>Expresses Alginate in the Lungs of Patients with Cystic Fibrosis and in a Mouse Model

Abstract

Anaerobiosis and lung infection rapidly induce alginate production by gene regulation in nonmucoid P. aeruginosa. This trait may contribute to early persistence, leading to chronic P. aeruginosa infection once stable mucoid strains are generated.