Downregulation of involucrin in psoriatic lesions following therapy with propylthiouracil, an anti‐thyroid thioureylene: immunohistochemistry and gene expression analysis

Abstract

In psoriasis, there is increased expression of involucrin, which leads to abnormal keratinocyte differentiation and hence to the formation of psoriatic plaques. The therapeutic effect of PTU in psoriasis may be attributable to the downregulation of involucrin. Larger trials should further elucidate the mechanism and therapeutic potential of PTU in psoriasis.