Differential teratogenesis of all‐<i>trans</i>‐retinoic acid administered on gestational day 9.5 to SWV and C57BL/6N mice: Emphasis on limb dysmorphology

Abstract

The malformation spectrum induced by RA was strain-specific, and the strain sensitivity for forelimb ectrodactyly was consistent with all previously tested teratogenic agents (i.e., C57BL/6N was more sensitive than SWV). The strain differences in teratologic effects were not explained by developmental timing differences or toxicokinetic differences at the whole-embryo level.