Chromatographic quality control of 99mTc-labeled compounds.

Abstract

The increasingly general use of a number of ssmTc@labeled compounds makes the need for an understanding of the capabilities of simple quality-control procedures urgent. A number of ssmTc radiopharmaceuticals which are already in general use have been studied in various chronwtographic procedures which might p0tentially provide adequate quality control. The comparative effectiveness of each of these chro matographic procedures for the accurate quality control of each radiopharmaceutical may be readily observed and an adequate procedure decided upon. The practical ease of handling and the technical skills necessary for the accu rate handling of each chromatographic system is discussed. It is recommended that quality control of sOmTc@lbumin be done on a Sepha dex G50 column and that of 9smTc@DTPA be done with thin-layer silica gel chromatography in both saline and acetone or butyl acetate. The quality-control procedure for SSmTc@polyphos@ phate is shown to be dependent on the commer cial kit which is used. Two such commercial kits are discussed.