Antiproliferative and apoptotic effects of the herbal agent <i>Pygeum africanum</i> on cultured prostate stromal cells from patients with benign prostatic hyperplasia (BPH)

Abstract

Results suggest that PA is antiproliferative and apoptotic on proliferative prostate fibroblasts and myofibroblasts but not on smooth muscle cells. Mechanisms of action include TGFB1 downregulation and inhibition of FGF2 specific signaling.